Human apoA-I increases macrophage foam cell derived PLTP

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A decrease in the plasma level of apoA-I protein was also demonstrated with another murine model of mild hyperhomocysteinemia, the Cbs +/− mouse Apolipoprotein A-I (ApoA-I), the major protein component of high-density lipoproteins (HDL) is a multifunctional protein, involved in cholesterol traffic and inflammatory and immune response regulation. The ATP-binding cassette transporter A1 (ABCA1) protein mediates the transport of cholesterol and phospholipids from cells to apolipoprotein A-I (apoA-I) to generate nascent HDL particles. Previous studies revealed that overexpression of ABCA1 or apoA-I … 2021-03-16 Apolipoproteins are protein components of plasma lipoproteins. The human apoA-I gene encodes a single chain, 243 amino acid protein which promotes cholesterol efflux from tissues to the liver for excretion.

Apolipoprotein A-I (apo A-I) is a protein that has specific roles in the transportation and metabolism of lipids and is the main protein component in high-density lipoprotein (HDL, the "good cholesterol").

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The aim of the current work was to evaluate whether the transcription of ApoA-I in chicken abdominal adipose tissue was regulated apoA-I Antibody (2G4) is a monoclonal antibody that detects mouse, rat and human apoA-I by WB, IP, IF and ELISA. Cited in 4 publications. ApoA-1 from rat (APOA1 ); E. coli, ≥ 98% SDS-PAGE, ≥ 98% HPLC; ApoA-I is a 29; Buy proteins and enzymes online from Sigma-Aldrich. The higher Met(O) content in apoA-I from diabetic patients is consistent with increased levels of lipid peroxidation products in plasma in diabetes.

Apoa-i

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Huvud apoB apoB apoB apoB apoA-I. protein. Huvud TG TG CE CE CE. lipid.

the apoB/apoA-I ratio, indicates cardiovascular risk; the higher the ratio, the higher is the risk. 2006 Blackwell Publishing Ltd Journal of Internal Medicine 259: 493–519 2008-04-23 Background and Purpose. Apolipoprotein A‐I (apoA‐I) mimetic peptides (AAMPs) are short peptides that can mimic the physiological effects of apoA‐I, including the suppression of atherosclerosis by reversely transporting peripheral cholesterol to the liver. 2006-03-06 2014-12-01 Sandwich ELISA: To detect Human ApoA-I by sandwich ELISA (using 100μl/well) a concentration of 0.5-2.0 μg/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech’s Biotinylated Anti-Human ApoA-I (500-P331BT) as a detection antibody, allows the detection of at least 2000-4000 pg/ml of Recombinant Human ApoA-I.
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Several reports have been published from the 1980s 42,43,44,45 for generation of anti-apoA-I mAbs based on the hybridoma method 46.In most of these studies, mice As a central constituent of HDL (high-density lipoprotein), apolipoprotein A-I (ApoA-I) has a vital function in lipid metabolism. Our previous studies confirmed that ApoA-I was differentially expressed in the adipose tissue of the abdomen of lean and fat broilers. The aim of the current work was to evaluate whether the transcription of ApoA-I in chicken abdominal adipose tissue was regulated apoA-I Antibody (2G4) is a monoclonal antibody that detects mouse, rat and human apoA-I by WB, IP, IF and ELISA.

ApoA-I, which is found exclusively in HDL, has a unique ability to capture and solubilize free cholesterol. This ApoA-I ability enables HDL to remove excess peripheral cholesterol, and return it to the liver for recycling and excretion.
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Structures of apolipoprotein A-I in high density lipoprotein

Once in the liver, cholesterol and phospholipids are redistributed to other tissues or removed from the body. ApoA-I is inversely associated with insulin resistance in patients with impaired glucose tolerance, and low apoA-I is an independent risk factor for impaired glucose tolerance (IGT). These results indicate that apoA-I plays an important role in regulating insulin sensitivity and glucose metabolism in patients with IGT. ApoA-I may be a protective blood-borne factor involved in the remote ischemic preconditioning mechanism. It maintains cholesterol homeostasis.


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APOA1 encodes a 45.4 kDa protein that is composed of 396 amino acids; 21 peptides have been observed through mass spectrometry data. Apolipoprotein A-I (apo A-I) is a protein that has specific roles in the transportation and metabolism of lipids and is the main protein component in high-density lipoprotein (HDL, the "good cholesterol").